CCS Chemistry 2025年第1期上线
CCS Chemistry 2025年第1期上线！本期包括2篇Mini-Review，3篇Communication和20篇Research Article。
本期封面文章来自吉林大学邹晓新等关于用于PEM水电解的高孔隙率氧化铱催化剂的研究论文。
Mini-Review来自 1）华南理工大学解增旗等关于太阳能利用的综述文章；2）中国科学院苏州纳米技术与纳米仿生研究所沈炎宾等关于离子-电子混合导体的综述文章。
Communication和Research Article涵盖了不对称合成、表面合成、电催化还原、单中心金属催化、酶催化、超分子催化、主客体识别、量子点、用于治疗的聚合物、水分解催化剂、硼掺杂分子碳、有机电子学等方面的最新研究进展。
了解更多信息，欢迎访问：https://www.chinesechemsoc.org/toc/ccschem/7/1。免费阅读下载整期文章。
2025年第1期
Editorial
2025年第1期主编寄语特别分享了美国建筑师理查德·巴克敏斯特·富勒（Richard Buckminster Fuller）的故事（分子“富勒烯”即以他的名字命名），他传奇的一生充满了对科技、设计和人类发展的思考和探索。新年伊始，我们满怀希望地迎接未来的挑战与未知，正是这种探索未知的过程让生活变得有趣。科学研究亦如此，自由地探索，不受失败的恐惧束缚。正如富勒所言“没有失败的实验，只有意料之外的结果”。
Cite this: CCS Chem. 2025, 7, 1-5
Link: https://doi.org/10.31635/ccschem.024.202401226ed1
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Author Spotlight
本期Author Spotlight邀请了华南理工大学解增旗、新加坡国立大学赵宇、吉林大学窦传冬三位老师分享科研经历中独特的心得和感悟。
Cite this: CCS Chem. 2025, 7, 6-9
Link：https://doi.org/10.31635/ccschem.024.202401219ed2
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以下是本期每篇文章的主编导读：
-Solar Energy Utilization. Photosensitizing systems having a single-photon process usually suffer from the inability to utilize low-energy photons from sunlight. Through a multiphoton strategy, mimicking the photosynthesis process in nature, this limitation can be overcome. In their review, Zengqi Xie (解增旗) and coworkers summarize multiphoton strategies for improving solar energy utilization efficiency in various artificial techniques, including photocatalysis, photoelectrodes, and solar cells. Moreover, they discuss potential uses of solution-based multiphoton strategies for solid-state devices.
Cite this: CCS Chem. 2025, 7, 10-21
Link: https://doi.org/10.31635/ccschem.024.202303827
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-Ionic-Electronic Conductors. Hui Shao (邵辉), Yanbin Shen (沈炎宾), and coworkers present a comprehensive exploration of the composition, preparation, key advantages, and basic characterization of organic mixed ionic–electronic conductors (OMIECs). The review then delves into recent research progress and future development of OMIECs in solid-state batteries, with a special focus on their applications in cathode coating layers, the creation of a 3D mixed conductive framework for Li hosting, and their integration as inner layers in Li anodes.
Cite this: CCS Chem. 2025, 7, 22-43
Link: https://doi.org/10.31635/ccschem.024.202404284
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-Phosphorus Chemistry. The nucleophilic phosphinylation of alkyl halides with phosphonites is a common method for synthesizing phosphinates; however, the approach is limited by high reaction temperatures and narrow applicability to primary alkyl halides. Chaozhong Li (李超忠) and coworkers develop a unique protocol for phosphinylation of alkyl halides at room temperature via a free radical mechanism. Their protocol is applicable to primary, secondary, and even structurally rigid tertiary alkyl bromides, and it can even be extended to the phosphinylation of alkyl iodides.
Cite this: CCS Chem. 2025, 7, 44-49
Link: https://doi.org/10.31635/ccschem.024.202404368
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-Cyclophane for Host–Guest Recognition. Cyclophanes are a type of macrocyclic molecule, each consisting of multiple aromatic rings, which are connected via a few bridging chains, including methylene units. Qing Li (李青), Feihe Huang (黄飞鹤), Hao Li (李昊), and coworkers report the design and synthesis of a cyclophane bearing two N-phenylene-bipyridinium units that are bridged in a face-to-face manner. The tetracationic cyclophane with a larger and longer cavity can recognize a variety of guests that are too large to be recognized within the known Bluebox.
Cite this: CCS Chem. 2025, 7, 50-58
Link: https://doi.org/10.31635/ccschem.024.202404345
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-Enzyme Catalysis. Dynobactin A is a ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotic that displays potent activity against Gram-negative bacteria. Qi Zhang (张琪) and coworkers successfully reconstitute the activity of the radical S-adenosylmethionine (SAM) enzyme, DynA, both in vivo and in vitro, and disclose that DynA catalyzes the formation of both C–C and N–C crosslinks in the biosynthesis of dynobactin A. Their findings provide new insights into radical SAM enzyme chemistry and open avenues for engineering novel RiPP antibiotics.
Cite this: CCS Chem. 2025, 7, 59-67
Link: https://doi.org/10.31635/ccschem.024.202404983
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-Mass Spectrometry Imaging in Living Cells. Oxidative stress is associated with various diseases, and therapeutic strategies targeting redox balance regulations exist. However, lack of knowledge about the heterogeneous metabolism and redox balance within different regions of tissues limits the development of redox-targeted therapies. Zongxiu Nie (聂宗秀) and coworkers employ mass spectrometry imaging to profile the redox and metabolic heterogeneity in response to oxidative stress induced by in situ synthesis of Au particles. Their study provides a new method to investigate the spatial metabolomic rewiring in tissues during oxidative challenge.
Cite this: CCS Chem. 2025, 7, 68-79
Link: https://doi.org/10.31635/ccschem.024.202404147
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-Enantioconvergent Heterocycle Synthesis. Bin-Miao Yang (杨彬淼), Yu Zhao (赵宇), and coworkers develop catalytic amination reactions of alcohols for the enantioconvergent synthesis of chiral C2- and C3-substituted benzomorpholines. Racemic amino alcohols of different substitution patterns, which can be prepared from a common precursor, are converted to enantioenriched heterocycles in a highly atom- and step-economical fashion. Impressively, asymmetric amination of racemic primary alcohols via dynamic kinetic resolution is achieved under cooperative iridium/iron catalysis, resulting in chiral C2-substituted benzomorpholines that are difficult to access otherwise.
Cite this: CCS Chem. 2025, 7, 80-90
Link: https://doi.org/10.31635/ccschem.024.202404559
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-Pnictogen-Bonding Catalysis. Pnictogen bonds are a type of noncovalent bond that have recently received considerable interest. Stefan Matile and coworkers report a comparative study on the catalytic and ion-transport properties of the two types of antimony-centered pnictogen bond donors, σ-acidic stibines and σ-acidic stiboranes. They found that σ-acidic stiboranes, with strong pnictogen bonds, provide unprecedented access to the Goldilocks inverted region. This study offers a unique tool to generalize the Goldilocks principle from transport to catalysis and from membranes to micelles.
Cite this: CCS Chem. 2025, 7, 91-104
Link: https://doi.org/10.31635/ccschem.024.202404847
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-Adaptive Assembly. Peifa Wei (魏培发), Ben Zhong Tang (唐本忠), and coworkers report the adaptive self-assembly of flexible crown ethers and rigid cyclophanes and successfully construct three distinct non-interwoven topological structures. In addition, they demonstrate the feasibility of harnessing the adaptability and selectivity of the flexible inner ring to realize dynamic responsiveness in the solid state with diverse emission behaviors.
Cite this: CCS Chem. 2025, 7, 105-115
Link: https://doi.org/10.31635/ccschem.024.202404130
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-Supramolecular Catalysis. Yan-Mei He, Qing-Hua Fan (范青华), and coworkers report an asymmetric Suzuki-Miyaura coupling reaction utilizing a crown ether moiety on a chiral diamine palladium complex to control enantioselectivity through supramolecular interactions. The catalytic system exhibits a high reactivity for the coupling of alkoxyl-substituted aryl iodides with various arylboronic acids, producing products with high enantioselectivity.
Cite this: CCS Chem. 2025, 7, 116-131
Link: https://doi.org/10.31635/ccschem.024.202404070
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-Electrocatalytic Nitrate Reduction. Electrocatalytic reduction of nitrate to ammonia is a promising approach to achieving sustainable ammonia synthesis and environmental denitrification. Yingji Zhao, Xiaodeng Wang, Feng Luo , Yunhai Liu (刘云海), and coworkers synthesize dynamic single-site metal catalysts by incorporating asymmetrical Co(II) complexes into a stable Th-metal–organic framework via covalent linkages. The resulting CoN2Cl2-based electrocatalyst achieves an outstanding ammonia production rate of 5135.3 mmol gcat−1 h−1 at −0.4 V, which is approximately 25 times higher than that of the Haber–Bosch process, outperforming other recently reported electrocatalysts.
Cite this: CCS Chem. 2025, 7, 132-147
Link: https://doi.org/10.31635/ccschem.024.202404641
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-Asymmetric Synthesis. Xiaoming Feng (冯小明), Shunxi Dong (董顺喜), and coworkers report rare-earth metal-catalyzed asymmetric addition/hydroamidination of nitriles and allylamines. A series of chiral bis(oxazolinato)rare-earth metal complexes are prepared and catalyze the enantioselective addition/hydroamidination of nitriles to allylamines, giving chiral 2-substituted imidazolines. Their approach provides a straightforward and atom-economical route to structurally diverse enantioenriched 2-susbtituted imidazolines in high yields and high enantioselectivity.
Cite this: CCS Chem. 2025, 7, 148-159
Link: https://doi.org/10.31635/ccschem.024.202403937
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-Luminescence Tuning of Quantum Dots. Guanjun Xiao (肖冠军) and coworkers apply high pressure as a tool to investigate the defect origin of chalcogenide quantum dots, and they successfully identify that surface hole traps predominantly contribute to defect emission, whereas nonradiative recombination is primarily associated with surface electron traps. Based on this photoluminescence mechanism, they achieve an energy-saving “neutral” white light with a human-eye-friendly color rendering index of 86 by tuning the defect emission through further elimination of surface cadmium sites.
Cite this: CCS Chem. 2025, 7, 160-169
Link: https://doi.org/10.31635/ccschem.024.202403971
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-On-Surface Synthesis. Xingguang Li (李星光), Pei-Nian Liu (刘培念), and coworkers report the formation of 2D networks through hierarchical on-surface synthesis utilizing multipoint noncovalent bonding, particularly S···N and S···H interactions. Their findings exemplify the effectiveness of multipoint noncovalent bonding in fabricating stable yet ordered 2D networks and could stimulate applications in the design and exploration of organic nanomaterials.
Cite this: CCS Chem. 2025, 7, 170-179
Link: https://doi.org/10.31635/ccschem.024.202303820
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-Therapeutic Polymers. Gao Li, Peng Zhang (张鹏), Chunsheng Xiao (肖春生), and coworkers develop a series of cationic spherical polypeptides (CSPs) with different lengths of poly-l-lysine segments for use in cancer therapy. Among them, CSP-57, with the longest poly-l-lysine segment, exhibits the best in vitro antitumor effect and tumor-cell-selective cytotoxicity by disrupting cell membranes and inducing cell necrosis. Furthermore, CSP-57 can effectively inhibit tumor growth with high biocompatibility in a mouse-bearing B16F10 melanoma model, representing a new kind of therapeutic polymer with inherent immune activation ability.
Cite this: CCS Chem. 2025, 7, 180-193
Link: https://doi.org/10.31635/ccschem.024.202303793
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-Asymmetric Dearomatization. Shu-Li You (游书力) and coworkers report a chiral phosphine-catalyzed asymmetric [3+2] annulation of benzimidazoles and cyclopropenones. The reaction provides the corresponding polycyclic chiral products in up to 98% yields and good enantioselectivity (up to 99% ee). The reaction has mild reaction conditions, excellent functional group tolerance, and compatibility with gram-scale synthesis.
Cite this: CCS Chem. 2025, 7, 194-204
Link: https://doi.org/10.31635/ccschem.024.202403981
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-Single-Organelle Analysis. Analyzing single organelles within the intricate compartmentalized systems of eukaryotic cells poses significant challenges in biomedical research. Tianxiang Wei (韦天香), Tao Gao (高涛), Zhihui Dai (戴志晖), and coworkers report a novel approach for single-organelle analysis in living cells. A delicately designed microelectrode device is used for the comprehensive analysis of single-organelle events, which is demonstrated by electrochemical analysis of mitochondrial parameters including ROS, ΔΨm, ATP, and their relationships.
Cite this: CCS Chem. 2025, 7, 205-215
Link: https://doi.org/10.31635/ccschem.024.202404066
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-Anode Catalysts for Water Splitting. Lowering iridium usage without sacrificing activity and durability is critical to the development of anode catalytic layers in proton exchange membrane water electrolyzers (PEMWE). Hui Chen (陈辉), Xiaoxin Zou (邹晓新), and coworkers present the synthesis of layered iridium oxide microparticles (p-L-IrO2) with an open porosity of approximately 74%. The p-L-IrO2 material is further employed to fabricate low-iridium-loading anode catalytic layers in PEMWE, which can afford excellent catalytic performance and retention of catalytic activity for 2300 h.
Cite this: CCS Chem. 2025, 7, 216-228
Link: https://doi.org/10.31635/ccschem.024.202303586
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-Hydrodehalogenation and Deuterodehalogenation. Terminal monohaloalkenes are common synthetic fragments used in organic synthesis and are also found in many natural products. Their Z/E stereoisomers are difficult to physically separate, which causes a persistent difficulty in functional molecular design and synthesis. Xi Lu (陆熹), Yao Fu (傅尧), and coworkers report complementary hydride and hydrogen radical generation pathways to enable hydrodehalogenation and deuterodehalogenation of gem-dihaloalkenes, producing stereo-defined deuterated or nondeuterated (Z)- and (E)-terminal monofluoroalkenes and (E)-terminal monochloroalkenes.
Cite this: CCS Chem. 2025, 7, 229-244
Link: https://doi.org/10.31635/ccschem.024.202403958
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-Reductive Cross-Coupling of Aryl Halides. Transition metal-catalyzed asymmetric reductive coupling of two electrophiles has emerged as a powerful tool for carbon–carbon bond formation; however, the enantioselective reductive cross-coupling of two aryl halides remains a challenge. Chao Zheng (郑超), Shu-Li You (游书力), Tian-Sheng Mei (梅天胜), and coworkers develop an enantioselective reductive cross-coupling reaction of two aryl halides by combining cobalt catalysis with electrochemistry to afford axially chiral biaryls with good chemoselectivities (cross-coupling: homo-coupling >20:1) and enantioselectivities. Moreover, this strategy can be extended to asymmetric cross-coupling of aryl and vinyl halides.
Cite this: CCS Chem. 2025, 7, 245-255
Link: https://doi.org/10.31635/ccschem.024.202403939
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-Boron-Doped Molecular Carbons. Chuandong Dou (窦传冬) and coworkers report the synthesis of two cove-edged boron-doped peri-acenes (C44B2 and C62B2), which represent an unprecedented type of defective boron-doped molecular carbons. Notably, the stimulated emission behavior and amplified spontaneous emission properties are realized for the C44B2 molecule, demonstrating the promising application of such organoboron π-systems for organic photonic and laser materials. Their study thus opens new avenues for synthetic and materials chemistry of defective molecular carbons.
Cite this: CCS Chem. 2025, 7, 256-265
Link: https://doi.org/10.31635/ccschem.024.202403953
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-Electrocatalytic Reduction of Nitrate. While much effort has been placed on the conversion of NO3− to ammonia, the exploration of other reactions for preparing high-value-added chemicals through NO3− reduction has had less attention but is still highly desirable. Liang Xu (徐亮), Zhenhua Li (栗振华), Mingfei Shao (邵明飞), and coworkers report an electrochemical strategy for synthesizing cyclohexanone oxime, an important feedstock in nylon-6 production, through hydrogenative coupling of NO3− and cyclohexanone using a titanium dioxide catalyst. Furthermore, they present a coupling reaction system to enable the simultaneous production of cyclohexanone oxime and cyclohexanone in a more environmentally friendly and economical approach.
Cite this: CCS Chem. 2025, 7, 266-278
Link: https://doi.org/10.31635/ccschem.024.202403988
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-Photoinduced Radical Migration. Qiuling Song (宋秋玲) and coworkers report photoinduced remote boryl and alkenyl radical migration reactions via boron complexes. They employ commercially available diboron reagent (B2pin2) or alkenyl boron (alkenylBpin) to react with o-bromostyrenes and their analogues in a single-vessel reaction, thus successfully promoting 1,4-, 1,5-, and even the challenging 1,6-radical migrations. The catalytic protocol shows good substrate scope, enabling a wide range of products with good yields.
Cite this: CCS Chem. 2025, 7, 279-292
Link: https://doi.org/10.31635/ccschem.024.202404075
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-Hydrogen-Bonded Organic Frameworks. Gangfeng Ouyang (欧阳钢锋), Gao-Feng Liu (刘高峰), and coworkers report a one-pot, gram-scale synthesis of a macrocycle-based hydrogen-bonded organic framework (mHOF) through the condensation of commercially available hydrazides and ketones. This mHOF material exhibits high thermal stability up to 400 °C and remarkable chemical stability. The materials also displays rapid, reversible adsorption of iodine owing to its intrinsic one-dimensional channels.
Cite this: CCS Chem. 2025, 7, 293-306
Link: https://doi.org/10.31635/ccschem.024.202404150
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-Fully Conjugated Azaacene Diimide. Azaacene diimides are expected to possess deep lowest unoccupied molecular orbital levels and narrower bandgaps while maintaining excellent solubility and enhanced stability compared to their parent acenes. However, the synthesis of fully conjugated azaacenes has been a long-time challenge. Wei Jiang (姜玮), Zhaohui Wang (王朝晖), and coworkers report a stepwise oxidation approach to successfully synthesize a series of fully conjugated tetraazahexacene diimides. Application in electronics and molecular electronics is highly anticipated.
Cite this: CCS Chem. 2025, 7, 307–315
Link: https://doi.org/10.31635/ccschem.024.202404126
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原标题：《CCS Chemistry 2025年第1期上线》